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A recent study in huntingtin knock-in striatal neuronal cells showed that CB1R protected neurons against excitotoxicity via PI3K/Akt signaling-mediated increase in brain-derived neurotrophic factor expression . In addition, CB1R-mediated PI3K/Akt activation has also been shown to modulate oocyte maturation and embryonic development . Moreover, the CB1R modulates the activity of several types of ion channels
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